Best Total Vegetation Killer for Large and Small Weeds

Ian Mutuli
Updated on
Ian Mutuli

Ian Mutuli

Founder and Managing Editor of Archute. He is also a graduate architect from The University of Nairobi, Kenya.
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The best total vegetation killer is a formula that will kill the self-growing plants that grown around the patio, in between concrete cracks, parking, under the deck, or sideways such as vegetations, grass, herbs, weeds, and suburbs. The total vegetation killers have chemical-based and organic formulas. The chemical formulas are highly toxic but will prevent regrowing for a long time, and organic formulas are safe for the environment and soil. Still, they have to be reapplied frequently at intervals to prevent regrowth.

In such cases, you will want to use the best total vegetation killers in the market, but it might be a daunting task to find the best one because there are plenty of products. Therefore, we have compiled a list of the best total vegetation killers with their pros and cons and a detailed buying guide to help you know what to look out for.

1. Ortho GroundClear Vegetation Best Weed Killer Concentrate

Ortho GroundClear Year Long Vegetation Killer Refill -...
  • Ortho GroundClear Year Long Vegetation Killer Refill kills weeds...
  • Fast-acting formula starts working immediately
  • Starts to kill weeds and grasses in 1 hour
  • Apply to driveways, sidewalks, gravel areas, rock and desert...
  • To use, attach a Comfort Wand from the original Ortho GroundClear...

Ortho GroundClear Vegetation best weed killer is a product using a non-selective weed formula that kills all plants on contact and because it comes in a concentrated form. It is a fast-acting formula that becomes rainproof in one hour once sprayed and will show you results within two hours. The formula contains active ingredients such as Isopropylamine salt, Pelargonic acid, and Imazapyr, even though they are not toxic.

Ortho GroundClear weed killer is suitable for use around fence rows, desert landscapes, under the deck, driveways, patio gravel areas, and also the parking. The formula kills weeds, grasses, and any vegetation from the root minimizing any chances for regrowth, but it has a toxic smell during application which disappears after about 30 minutes.


  • Prevents weed up to 12 months
  • It comes with a ready-to-use sprinkler cup
  • OMRI listed meaning it is an organic product
  • Easy to use the product
  • Control weed and prevents new weeds from growing
  • Friendly pricing
  • The herbicide is suitable for clearing hard surfaces like walkways, patios, or paths.


  • The product is not ideal for a lawn with desirable vegetables and flowers
  • Limited coverage

2. RM43 43-Percent Glyphosate Plus Weed Preventer Total Vegetation Control

RM43 43-Percent Glyphosate Plus Weed Preventer Total...
  • Kills weeds and prevents weeds for up to 1 year
  • Treats 17,297 square feet
  • Ideal for fence rows, gravel paths, sidewalks, driveways, parking...
  • Apply to locations only where no vegetation is desired
  • Can be used for total vegetation control (bare ground) or spot...

RM43 43-Percent Glyphosate weed killer is a powerful herbicide that uses glyphosate as one of the main active ingredients and can eliminate brush, shrubs, grass, and weeds affecting your drive or walkways. 1 gallon of the liquid can treat about 17,297 square feet (sq. ft), and it needs to be mixed with a gallon of water for maximum effectiveness.

RM43 43-Percent weed killers don't come with an application method, and you need to purchase an additional system or sprayer. However, the weed killer is worth it as it is one of the only vegetation killers that perfectly get rid of thick brush in rural areas like farms.


  • Results are visible in a week
  • It can last for about twelve months
  • The herbicide is suitable for fence lines and farms
  • Covers 17,297 square feet (sq. ft) per gallon, which is a large area


  • No extra application is needed

3. Southern Ag 2,4-D Amine Weed Killer

Southern Ag Amine 2,4-D WEED KILLER, 32oz - Quart
  • Selective Broadleaf Weed Control
  • For use in pastures & rangeland, lawns, golf courses, cemeteries,...

Southern Ag 2,4-D is the best vegetation killer for controlling the annual growth of grasses and weeds. It can be used around the landscape and container-grown ornamentals, industrial sites, and around the non-bearing fruit trees as a pre-emergent selective weed killer. The herbicide will continue on top of the weed, grass, or vegetation because it is a surface-applied product, and you can pour water on its surface.

Southern Ag weed killer can be used to control buffalograss, St. Augustine, centipede grass, zoysia grass, Bermuda grass, and Bahiagrass. You will need less than 1.5 ounces to treat a 1000 square feet(sq. ft) area, and a single application will last about four months, which prevents weeds from growing and seeds from germinating. Once you water your garden, you will need to water your lawn again within 21 days, and it can be mixed with other related plant killers such as Vantage or Roundup.


  • The product can be used for large areas and also on lawns
  • It comes with a friendly pricing
  • The weed preventer is quite effective at differentiating between grass and weeds.
  • It is the best weed killer to kill popular grass strains such as St. Augustine's.
  • Effective on most broadleaf weeds


  • It is not child or pet friendly
  • The non-selective product can harm even the desired plants.

4. Spectracide Weed Stop for Lawns Concentrate

Spectracide Weed Stop For Lawns Concentrate, Kills Weed...
  • KILLS WEEDS, NOT THE LAWN: Won’t harm lawns when used as...
  • CONTROLS ALL MAJOR BROADLEAF WEEDS: Controls dandelion, chickweed...
  • KILLS THE ROOT: See overnight results
  • RAINPROOF: Rainfall or watering 6 hours after application will...
  • COVERAGE: 40 ounce bottle treats up to 20,000 square feet

Spectracide Weed Stop is the best weed killer to eliminate unwanted plants or weeds on non-lawn areas such as patios or gravel paths, and the weed killer will kill almost all types of plants. The concentrate is a fast-acting formula that will show you visible results within about four hours, and it can eliminate up to 115 different weed species with ease, focusing on the roots.

Compared to other weed killers, this concentrate delivers consistent results and kills weeds without damaging the surrounding plants and flowers. In addition, the herbicide will apply a protective layer onto your soil that will act as a barrier and prevent weeds and grass from growing and can be used on stubborn plants and weeds like dandelions or clovers.


  • The concentrate will not get washed away with wind or rain easily
  • It will show visible results within a minimum of three hours
  • The weed killer kills grass and weeds to the root system
  • The weed and grass killer formula is ready to use
  • The weed grass formula can be applied to various places
  • It controls the major broadleaf weeds


  • The weed preventer should not be used around edibles
  • It contains chemicals, so you need to be careful when handling it
  • Unsuitable for lawn use

5. Compare-N-Save Grass and Weed Killer

Compare-N-Save 75324 Herbicide, 1-gallon, white
  • Rainproof in 2 hours
  • Visible results in as little as 2 to 4 days
  • Contains 41-percent glyphosate
  • Covers over 25,000 square feet
  • Makes up to 85 gal. of ready-to-use spray. Note: Packaging may...

Compare-N-Save non-selective weed killer is an ideal choice to kill weeds and unwanted plants in your lawn or garden and is often thought to be a nuclear bomb because it's very powerful. The formula is made with glyphosate, which prevents weeds and plants from creating the needed protein for growth and acts within about two weeks or less after application.

Compare-N-Save weed killer will clear all weeds and plants in your lawn or garden even when applied in minimum volumes, but you need to be careful, especially for spot treatments. The herbicide is too powerful hence calling for extra caution. If you accidentally apply on any desired flowers, vegetables, or plants, you should apply some water and wash the formula off immediately.


  • Immediate effect as the grass killer eliminates plants within two to four days.
  • The herbicide does not easily wash away
  • Suitable for
  • Covers over 25,000 square feet (sq. ft)
  • Easy to use as it is straightforward
  • Specifically targets plants, and it is suitable for landscapes, sidewalks, or gardens.


  • Not ideal for use around domesticated animals
  • Your lawn might need several gallons of spray

What Are The Advantages Of Using The Best Vegetation Killer Products?

a). Leaves No Soil Residue

Most plant killers focused on the roots usually leave minimum if any soil residue because once the plant killer hits the soil, the clay particles become inactive. Therefore, you will easily be able to spray weeds or undesirable plants beneath trees and shrubs without causing damage to the desired plants.

b). Effective Weed Control

Effective weed control is the major pro of using vegetation killers as these products are very effective at killing weeds. In addition, there are selective weed killers that will kill the specific plant or weed types and non-selective weed products that will kill all types of weeds.

c). Ease Of Use

Pulling plants, grasses, and weeds from the soil can be strenuous, and you will have to be on your knees to start pulling them, and these might put a lot of strain on your back and legs. However, a vegetative killer is very simple to apply. All you need to do is spray the solution all over the plant. Then, the chemical will take over and kill all the unwanted vegetation.

d). Kills All Plants And Weeds

Vegetative killers are quite effective in killing all vegetation types, including weeds. They are one of the best options for clearing the driveways, patios, play areas,s or parking areas. They will kill all vegetation down to their roots and prevent their regrowth for up to a year.

Should You Take Any Precautions While Using Total Vegetation Killers?

While using total vegetation killers, there is no immediate danger that you will be exposed to. Still, if you are exposed to several plant killers, the exposure can cause some toxicity levels in the human body. Additionally, short-term exposure can irritate your skin and eyes, and if you breathe the vegetation killer in, it can cause and irritation to your nose and throat.

However, always ensure you wear protective gear like eyewear and gloves while handling these herbicides. Also, while glyphosate is not usually absorbed by the skin, it is advisable to wash your hands after using or touching any plants you might have applied or sprayed the chemical on.

What to Consider Before Purchasing the Best Total Vegetation Killer

1. Ingredients

Most weeds, grasses, and vegetation killers usually contain the same main ingredients unless they have an organic formula where chemicals are avoided and replaced with vinegar. The most common ingredients used in these weed and grass killer products include acetic acid, glyphosate, clethodim, sethoxydim, fluazifop-p-butyl, pelargonic acid, and metam sodium.

Acetic acid is a professional name for vinegar, but the other active ingredients are toxic compounds targeted towards different weeds and grasses in your garden. Therefore, before you choose the best vegetation killer, ensure you check all the included ingredients to try and eliminate the ingredients that will work well.

2. Longevity

The majority of weed killers usually claim to last between six to twelve months, but this period will vary when using. Organic weed killing will have the shortest lifespan as they are not effective when it comes to killing the roots, and hence they need application more often. However, most gardeners expect a natural weed killer to last between three to four months with frequent applications.

On the other hand, when using a chemical weed killer, you will be able to kill and control weeds, and they are usually gone for up to a year before you start seeing new weeds. This is because the herbicide ingredients usually go underneath the concrete or any other substances and attack the roots directly. So in most cases, it completely kills the weeds growing for good.

Also, when considering longevity, ensure the product you choose is rain-ready, meaning the formula will be effective even during the rainy season and will not be washed out with the rain. Different vegetation killers vary where some are rain-ready within an hour or less, and some take up to 48 hours to get fully integrated into the roots of brush and weeds.

3. Spreading Method

The spread method is how you intend to use the weed killer on your garden, and the most common way to apply the herbicide is to use a spray but keep in mind that most herbicides are not sold with the sprayer. If the weed killer does not include an attached sprayer, you have to figure out if you will use a hand sprayer such s a bottle or a machine wand that will allow you to direct the weed killer to any target areas. If you need the grass and weed killer for a large area, remember to use a large backpack spray to get the best coverage.

Frequently Asked Questions

1. Are glyphosate weed killers harmful to humans?

Glyphosate herbicides cause eye and skin irritation issues and can also burn your mouth, causing excess salivation if they accidentally enter your mouth. Therefore, it's always recommended that you wear protective gear while handling these glyphosate herbicides.

2. How Long Does It Take for a vegetation killer to Work?

The amount of time it will take depends on the brand you will be using, where some start working immediately; with some, you will see visible results within an hour or two, and other weed killers will show results after up to two weeks. Check your packaging to know when to expect results.

3. When should you apply a vegetation killer?

You should spray the weed killer during the day when the temperature is at least 16 degrees Celsius or warmer because the weed preventer works best with heat and sunlight present. That doesn't mean you won't get results if the temperatures are colder than that but ensure that there hasn't been a lot of rainfall before you spray, and also, it will not rain afterward. Also, it's important to consider the wind speed because if it's too windy, the product could also cover the desired plants and if you must spray a weed killer on a windy day, try covering the plants that you don't want to kill.

4. What are the different vegetation killer products types?

There are two main chemical types in plant killers or vegetation killers: contact and systematic. Contact killers kill what they touch and are mostly used for plant leaves and grass blades, whereas a systematic herbicide will be absorbed by plants through the leaves and will travel throughout the body, including the roots killing every plant part within 24 hours.

Additionally, most vegetation killers are non-selective, and others are selective where they will help a gardener get rid of the problematic plants without harming the surrounding plants. Also, for killing grassroots, you can choose between the pre-emergent and post-emergent herbicides where the pre-emergent products prevent weed seeds from germinating, and post-emergent herbicides are made from the mature plants to kill weeds from the roots.

Ian Mutuli

About the author

Ian Mutuli

Founder and Managing Editor of Archute. He is also a graduate architect from The University of Nairobi, Kenya.
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